Kaempferol inhibited bovine herpesvirus 1 replication and LPS-induced inflammatory response | Zendy

Lei Zhu | Zendy; P. WANG | Zendy; Wenbing Yuan | Zendy; Guangduo Zhu | Zendy

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Kaempferol inhibited bovine herpesvirus 1 replication and LPS-induced inflammatory response

Author(s) -

Lei Zhu,

P. WANG,

Wenbing Yuan,

Guangduo Zhu

Publication year - 2018

Publication title -

acta virologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.412

H-Index - 33

eISSN - 1336-2305

pISSN - 0001-723X

DOI - 10.4149/av_2018_206

Subject(s) - kaempferol , u937 cell , tumor necrosis factor alpha , in vitro , viral replication , bovine herpesvirus 1 , biology , virology , virus , quercetin , herpesviridae , immunology , biochemistry , viral disease , antioxidant

Plant-derived flavonoids contain large amount of compounds with pharmacological effects. In this study, we showed the compound Kaempferol to have robust antiviral activity against bovine herpesvirus 1 (BoHV-1) replication in vitro. Kaempferol at a concentration of 100 μmol/l completely inhibited viral replication in MDBK cells. It mainly affects the viral replication at the post-entry stages. The inhibition of Akt signaling is a potential mechanism underlying the antiviral effect of Kaempferol. In addition, at a concentration of 25 and 50 μmol/l Kaempferol could significantly reduce the expression of inflammatory mediators such as tumor necrosis factor alpha (TNF-α), interleukin-8 (IL-8) and macrophage inflammatory protein 1 alpha (MIP-1α) in human promonocytic U937 cells-derived macrophages (dU937) in response to lipopolysaccharides (LPS) stimulation. Overall, our results indicated that Kaempferol provides a potent protection against BoHV-1 infection and LPS-induced inflammatory response.

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