Open AccessApproaches to Gradual Dose Reduction of Chronic Off-Label Antipsychotics Used for Behavioral and Psychological Symptoms of Dementia
Author(s) -
Jennifer Tjia,
Marcus M. Reidenberg,
Jacob N. Hunnicutt,
Kelli Paice,
Jennifer L. Donovan,
Abir O. Kanaan,
Becky A. Briesacher,
Kate L. Lapane
Publication year - 2015
Publication title -
the consultant pharmacist
Language(s) - English
Resource type - Journals
eISSN - 2331-0936
pISSN - 0888-5109
DOI - 10.4140/tcp.n.2015.599
Subject(s) - discontinuation , antipsychotic , medicine , dementia , randomized controlled trial , psychiatry , clinical trial , schizophrenia (object oriented programming) , disease
Little is known about how to best taper antipsychotics used in patients with dementia. To address this gap, we reviewed published antipsychotic discontinuation trials to summarize what is known about tapering strategies for antipsychotics used with older adults with dementia. We further developed pharmacokinetic-based gradual dose reduction (GDR) protocols based on antipsychotic half-lives.