Open AccessPancytopenia with hemophagocytic lymphohistiocytosis in Plasmodium falciparum: A unusual presentation
Author(s) -
Shewta Chaudhry,
Aditi Arya,
Monika Matlani,
Vineeta Singh,
Swati Meena
Publication year - 2021
Publication title -
tropical parasitology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.418
H-Index - 11
eISSN - 2229-7758
pISSN - 2229-5070
DOI - 10.4103/tp.tp_34_20
Subject(s) - pancytopenia , hepatosplenomegaly , malaria , hemophagocytic lymphohistiocytosis , malignancy , medicine , presentation (obstetrics) , plasmodium falciparum , pediatrics , immunology , intensive care medicine , pathology , disease , surgery , bone marrow
Hematological manifestations such as anemia and thrombocytopenia are known complications in malaria. Here, we report two cases presented as pancytopenia with hepatosplenomegaly and initial diagnosis kept as hematological malignancy like leukemia but later on its diagnosed as malaria-associated hemophagocytic lymphohistiocytosis which is a rare entity. The aim of this report is to draw the attention of physicians, especially in tropical countries such as India and Sub-Saharan nations to keep in mind this uncommon presentation of malaria, though the exact pathophysiological mechanism still remains obscure.