Open AccessL-cysteine whether a nutritional booster or a radical scavenger for Plasmodium
Author(s) -
Sanjib Sinha,
CS Gautam,
Rakesh Sehgal
Publication year - 2021
Publication title -
tropical parasitology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.418
H-Index - 11
eISSN - 2229-7758
pISSN - 2229-5070
DOI - 10.4103/tp.tp_20_18
Subject(s) - chloroquine , plasmodium falciparum , cysteine , biology , amino acid , growth inhibition , ic50 , in vitro , in vivo , plasmodium (life cycle) , pharmacology , biochemistry , malaria , parasite hosting , immunology , genetics , world wide web , computer science , enzyme
Plasmodium falciparum is the most noxious species among other Plasmodium species that cause malaria. Attention is required to understand more about the pathophysiology and parasite biology to obscure this disease. The fact is, very little is known about the nutritional requirement in sense of carbohydrate, lipid, nucleic acid, and amino acid metabolism that regulate the growth of parasite and out of this, studies related to the metabolism of amino acid are exceptionally limited. Out of several amino acids, L-cysteine is essential for the continuous erythrocytic growth of Plasmodium . However, the exact role of L-cysteine in regulating the growth of Plasmodium is unknown. Here, we tried to investigate how does L-cysteine affects the growth of Plasmodium in in vitro culture, and also the study was aimed to find whether there is a synergism with chloroquine on the Plasmodium growth in vitro .