Open AccessIdentification and characterization of glycine decarboxylase as a direct target of snail in the epithelial–mesenchymal transition of cancer cells
Author(s) -
Guohua Chen,
Jianmei Wu,
Jing Li,
Jian Wang
Publication year - 2018
Publication title -
tumor and microenvironment
Language(s) - English
Resource type - Journals
eISSN - 2589-5508
pISSN - 2395-7182
DOI - 10.4103/tme.tme_8_18
Subject(s) - biology , snail , epithelial–mesenchymal transition , transcription factor , microbiology and biotechnology , serine , carcinogenesis , cancer cell , gene knockdown , biochemistry , gene , downregulation and upregulation , phosphorylation , genetics , cancer , ecology
Metabolic reprogramming and cellular plasticity drive tumorigenesis. However, how these cellular events collectively contribute to the oncogenic process is poorly understood. Epithelial-mesenchymal transition (EMT), a fundamental mechanism of cellular plasticity, is governed by the EMT transcription repressors such as Snail. In the present study, through establishment and characterization of inducible overexpression of Snail in A549 lung cancer cells, we aim to define the metabolic reprogramming in response to Snail in the EMT of lung cancer cells.