Open AccessThe serum sclerostin level is positively associated with the aortic augmentation index in patients on peritoneal dialysis
Author(s) -
Lin Lin,
YuHsien Lai,
Liang-Te Chiu,
Jen-Pi Tsai,
ChihHsien Wang,
BangGee Hsu
Publication year - 2019
Publication title -
tzu-chi medical journal/cí-jì yīxué
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.343
H-Index - 15
eISSN - 2223-8956
pISSN - 1016-3190
DOI - 10.4103/tcmj.tcmj_90_18
Subject(s) - medicine , sclerostin , blood pressure , body mass index , cardiology , arterial stiffness , peritoneal dialysis , creatinine , endocrinology , wnt signaling pathway , biochemistry , chemistry , gene
Sclerostin is a canonical Wingless (Wnt)/β-catenin signaling pathway inhibitor and had been associated with high arterial stiffness in patients with chronic kidney disease. The aortic augmentation index (AIx), a noninvasive method of assessing central hemodynamics/wave reflections, has been widely used as a clinical index of arterial stiffness. The aim of this study was to evaluate the relationship between fasting serum sclerostin levels and AIx values in peritoneal dialysis (PD) patients.