Open AccessTransplanting human umbilical cord mesenchymal stem cells and hyaluronate hydrogel repairs cartilage of osteoarthritis in the minipig model
Author(s) -
Kun-Chi Wu,
Yu-Hsun Chang,
Hwan-Wun Liu,
Dah-Ching Ding
Publication year - 2019
Publication title -
tzu-chi medical journal/cí-jì yīxué
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.343
H-Index - 15
eISSN - 2223-8956
pISSN - 1016-3190
DOI - 10.4103/tcmj.tcmj_87_18
Subject(s) - mesenchymal stem cell , medicine , cd90 , umbilical cord , chondrogenesis , type ii collagen , aggrecan , osteoarthritis , cartilage , pathology , transplantation , stem cell , hyaluronic acid , cd34 , andrology , anatomy , surgery , microbiology and biotechnology , biology , articular cartilage , alternative medicine
Osteoarthritis (OA) is a chronic disease of degenerative joints. Mesenchymal stem cells (MSCs) have been used for cartilage regeneration in OA. We investigated the therapeutic potential of human umbilical cord-derived MSCs (HUCMSCs) with hyaluronic acid (HA) hydrogel transplanted into a porcine OA preclinical model.