Open AccessAssociation of metabolic traits with occurrence of nonalcoholic fatty liver disease-related hepatocellular carcinoma: A systematic review and meta-analysis of longitudinal cohort studies
Author(s) -
Cheqing Jin,
Shu Song,
LI Xiang-su,
Dongxue Bian,
Xudong Wang
Publication year - 2022
Publication title -
the saudi journal of gastroenterology/saudi journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 32
eISSN - 1998-4049
pISSN - 1319-3767
DOI - 10.4103/sjg.sjg_260_21
Subject(s) - medicine , nonalcoholic fatty liver disease , hepatocellular carcinoma , cirrhosis , gastroenterology , dyslipidemia , fatty liver , diabetes mellitus , metabolic syndrome , overweight , steatosis , incidence (geometry) , obesity , disease , endocrinology , physics , optics
Nonalcoholic fatty liver disease (NAFLD) has become one of the leading etiologies of hepatocellular carcinoma (HCC), but risk factors for NAFLD-related HCC occurrence have not been defined. NAFLD is often complicated by metabolic abnormalities, and there is a bidirectional association of metabolic abnormalities with NAFLD progression. This study aimed to systematically evaluate the relationship between metabolic traits and HCC occurrence in patients with NAFLD.