Open AccessThe effect of low versus high tidal volume ventilation on inflammatory markers in animal model undergoing lung ventilation: A prospective study
Author(s) -
Waseem Hajjar,
Abdelazeem Eldawlatly,
Sami Alnassar,
Ahmed Idbaïh,
Alaa Alghamedi,
Zahid Shakoor,
Ammar C. Al-Rikabi,
Adnan W Hajjar,
Abdulaziz Ahmad
Publication year - 2021
Publication title -
saudi journal of anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.416
H-Index - 24
eISSN - 1658-354X
pISSN - 0975-3125
DOI - 10.4103/sja.sja_650_20
Subject(s) - medicine , beagle , lung , mechanical ventilation , tidal volume , prospective cohort study , ventilation (architecture) , thoracotomy , bronchoalveolar lavage , pathology , anesthesia , gastroenterology , respiratory system , surgery , mechanical engineering , engineering
Mechanical ventilation (MV) with high tidal volume (Vt.) may induce or aggravate lung injury in critically ill patients. It might also cause an overwhelming systemic inflammation leading to acute lung injury (ALI), diffuse alveolar damage (DAD) and multiple organ failure (MOF) with subsequent high mortality. The objective of this study was to compare the effects of different Vt. on the inflammatory markers of the broncho-alveolar lavage (BAL) fluid and lung biopsy in a group of animal model (Beagle dogs).