Open AccessUnraveling the spectrum of KIT mutations in gastrointestinal stromal tumors: An Indian Tertiary Cancer Center Experience
Author(s) -
Trupti Pai,
Munita Bal,
Omshree Shetty,
Mamta Gurav,
Vikas Ostwal,
Anant Ramaswamy,
Mukta Ramadwar,
Sangeeta Desai
Publication year - 2017
Publication title -
south asian journal of cancer
Language(s) - English
Resource type - Journals
eISSN - 2278-4306
pISSN - 2278-330X
DOI - 10.4103/sajc.sajc_275_16
Subject(s) - medicine , stromal cell , tertiary care , center (category theory) , cancer , oncology , cancer research , chemistry , crystallography
Primary mutations in the KIT gene are the driving force for gastrointestinal stromal tumors (GIST) tumorigenesis. Predictive role of KIT mutation status aids oncologists in patient management. There is a paucity of comprehensive data on the frequency of mutations in the KIT gene in GIST affecting Indian patients. The aims of this study were to determine the frequency and spectrum of molecular alterations affecting the KIT gene and assess their association with clinicopathologic features in a cohort of patients of GIST.