Open AccessTranscriptomics and sequencing analysis of gene expression profiling for major depressive disorder
Author(s) -
Pragya Verma,
Madhvi Shakya
Publication year - 2021
Publication title -
indian journal of psychiatry/indian journal of psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.485
H-Index - 34
eISSN - 1998-3794
pISSN - 0019-5545
DOI - 10.4103/psychiatry.indianjpsychiatry_858_20
Subject(s) - major depressive disorder , transcriptome , gene expression profiling , gene , bipolar disorder , psychiatry , bioinformatics , psychology , medicine , gene expression , genetics , biology , mood
Major depressive disorder (MDD) is a common psychiatric disorder characterized by constant sadness and a lack of interest in work and social interactions. Maintaining the transcriptome levels via the controlled regulation of mRNA processing and transport is essential to alleviating MDD. Various molecular phenotypes such as aberrant RNA splicing and stability are identified as critical determinants of MDD.