Open AccessTelomere length and 8-hydroxy-2-deoxyguanosine as markers for early prediction of Alzheimer disease
Author(s) -
Dalia H Abou-Elela,
Rawhia H El-Edel,
Ahmed Shalaby,
Mariam A Fouaad,
Ahmed A Sonbol
Publication year - 2020
Publication title -
indian journal of psychiatry/indian journal of psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.485
H-Index - 34
eISSN - 1998-3794
pISSN - 0019-5545
DOI - 10.4103/psychiatry.indianjpsychiatry_783_19
Subject(s) - telomere , oxidative stress , medicine , random hexamer , alzheimer's disease , biomarker , endocrinology , deoxyguanosine , cellular aging , inflammation , disease , biology , gene , microbiology and biotechnology , gastroenterology , genetics
Becoming shorter by each cell division, telomere length (TL) is regarded as a marker of cellular aging. Relative TL (T/S) depends on the quantitation of telomere hexamer repeat copy number normalized to autosomal single-copy gene copy number. TL is influenced by several factors, including oxidative stress (OS) and inflammation. This study aimed to investigate the possible role of TL and OS as markers for Alzheimer's disease (AD).