Open AccessPrediction of schizophrenia using MAOA-uVNTR polymorphism: A case–control study
Author(s) -
Jelena Culej,
Nora Nikolac Gabaj,
Mario Štefanović,
Dalibor Karlović
Publication year - 2020
Publication title -
indian journal of psychiatry/indian journal of psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.485
H-Index - 34
eISSN - 1998-3794
pISSN - 0019-5545
DOI - 10.4103/psychiatry.indianjpsychiatry_54_19
Subject(s) - serotonin transporter , dopamine transporter , psychiatry , schizophrenia (object oriented programming) , medicine , genotyping , genotype , psychology , genetics , biology , dopamine , dopaminergic , serotonin , gene , receptor
Schizophrenia has been associated with disorder of the dopamine system, which is downregulated by projections of the serotonin pathway. Dopamine and serotonin levels are regulated by a system of transporters and enzymes. In this research, dopamine transporter polymorphism (DAT-VNTR), serotonin transporter polymorphism (5-HTTLPR), monoamine oxidase A (MAOA-uVNTR), and catechol-o-methyl transferase (COMT Val158Met) polymorphisms have been investigated.