Open AccessGlutamatergic augmentation strategies in obsessive–compulsive disorder
Author(s) -
Karthik Shunmugavelu,
Janardhanan C. Narayanaswamy
Publication year - 2019
Publication title -
indian journal of psychiatry/indian journal of psychiatry
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.485
H-Index - 34
eISSN - 1998-3794
pISSN - 0019-5545
DOI - 10.4103/psychiatry.indianjpsychiatry_520_18
Subject(s) - glutamatergic , pharmacotherapy , obsessive compulsive , psychology , medicine , neuroscience , psychiatry , glutamate receptor , receptor
Proven treatment strategies for obsessive-compulsive disorder (OCD) include pharmacotherapy with serotonin reuptake inhibitors and cognitive behavior therapy (CBT). A significant proportion of patients (25%-30%) fail to respond to these treatment options, necessitating the need for additional treatment options to improve treatment outcomes and quality of life in patients with OCD. Augmentation strategies using various glutamatergic agents have been explored, with diverse outcomes. The aim of this review is to give an overview of the glutamatergic system in the brain with a focus on glutamatergic abnormalities in OCD and to review the existing evidence for various glutamatergic agents used for augmentation.