Open AccessDifferential impact of interleukin-6 promoter gene polymorphism on hippocampal volume in antipsychotic-naïve schizophrenia patients
Author(s) -
Venkataram Shivakumar,
Vanteemar S. Sreeraj,
Manjula Subbanna,
Sunil V. Kalmady,
Anekal C. Amaresha,
Janardhanan C. Narayanaswamy,
Monojit Debnath,
Ganesan Venkatasubramanian
Publication year - 2020
Publication title -
indian journal of psychiatry/indian journal of psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.485
H-Index - 34
eISSN - 1998-3794
pISSN - 0019-5545
DOI - 10.4103/psychiatry.indianjpsychiatry_486_19
Subject(s) - genotype , hippocampal formation , medicine , single nucleotide polymorphism , hippocampus , magnetic resonance imaging , polymorphism (computer science) , subiculum , endocrinology , microbiology and biotechnology , psychology , biology , genetics , gene , radiology , dentate gyrus
Differential susceptibility model hypothesizes that a genotype need not be unfavorable all the time as postulated in stress-diathesis model but can be beneficial in a supportive context. Single-nucleotide polymorphism (SNP) (rs18000795) within the promoter region of interleukin-6 (IL-6) gene was earlier noted to have a differential susceptibility on hippocampal volume in schizophrenia (SCZ).