Open AccessAllium sativum constituents exhibit anti-tubercular activity In vitro and in RAW 264.7 mouse macrophage cells infected with Mycobacterium tuberculosis H37Rv
Author(s) -
Swapna S. Nair,
Sujay Gaikwad,
Supriya Kulkarni,
Alka Mukne
Publication year - 2017
Publication title -
pharmacognosy magazine
Language(s) - English
Resource type - Journals
eISSN - 0976-4062
pISSN - 0973-1296
DOI - 10.4103/pm.pm_435_16
Subject(s) - cytotoxicity , allium sativum , mycobacterium tuberculosis , resazurin , in vitro , macrophage , biological activity , intracellular , chemistry , tuberculosis , microbiology and biotechnology , biology , traditional medicine , biochemistry , medicine , botany , pathology
Long duration of treatment, side-effects of currently used anti-tubercular drugs and emergence of drug-resistant forms of Mycobacterium tuberculosis (MTB) warrants the need to develop new drugs to tackle the scourge of tuberculosis (TB). Garlic is an edible plant reported to have anti-tubercular activity. However, previous researches on anti-tubercular effect of garlic were focused mostly on preliminary in vitro screening.