Open AccessAssociation of angiotensin-converting enzyme, CYP46A1 genes polymorphism with senile cataract
Author(s) -
Syed Tasleem Raza,
Shania Abbas,
Anu Chandra,
Luxmi Singh,
Saliha Rizvi,
Farzana Mahdi
Publication year - 2017
Publication title -
oman journal of ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.306
H-Index - 16
eISSN - 0974-7842
pISSN - 0974-620X
DOI - 10.4103/ojo.ojo_40_2015
Subject(s) - senile cataract , angiotensin converting enzyme , medicine , genotype , polymorphism (computer science) , restriction fragment length polymorphism , gene , ophthalmology , genetics , biology , blood pressure
Senile cataract is the most common type of cataract characterized by gradual progressive thickening of the lens of the eye. Previously, many studies investigated the association between genetic polymorphism and senile cataract. Angiotensin-converting enzyme ( ACE ) I/D polymorphism is the potential risk factor for many eye-related diseases such as retinopathy and glaucoma. CYP46A1 enzyme converts cholesterol to 24S-hydroxycholesterol; human lens' membranes contain the highest cholesterol content. Defects in enzymes of cholesterol metabolism can be associated with cataracts. Hence, the present study was carried out to investigate the association of ACE and CYP46A1 genes polymorphism with senile cataract cases and controls.