Open AccessEvaluation of mast cells in oral premalignant and malignant lesions: A histochemical study
Author(s) -
Shreya Singh,
Vishakha Gupta,
Ruchieka Vij,
Rashmi Aggarwal,
Bhagwat Swaroop Sharma,
Madhav Nagpal
Publication year - 2018
Publication title -
national journal of maxillofacial surgery
Language(s) - English
Resource type - Journals
eISSN - 2229-3418
pISSN - 0975-5950
DOI - 10.4103/njms.njms_49_17
Subject(s) - medicine , epithelial dysplasia , pathology , leukoplakia , dysplasia , mast cell , oral submucous fibrosis , oral lichen planus , oral mucosa , fibrosis , connective tissue , epithelium , carcinoma , cancer , immunology
Oral leukoplakia, oral submucous fibrosis, and oral lichen planus are the precancerous or potentially malignant lesions and conditions whereas oral squamous cell carcinoma (OSCC) is a cancerous or malignant lesion of the oral cavity. They have characteristic clinical and histopathological features. These diseases not only originate from epithelium but also associated with chronic inflammation juxta-epithellialy. Mast cells present in the connective tissue stroma and release pro-inflammatory and mitogenic cytokines. These functions of mast cells contribute and enhance the pathogenesis translation of diseases.