Open AccessPrevalence of Cytochrome P450 2B6 Single Nucleotide Polymorphism in an HIV-Positive Cohort in Jos, Nigeria: Implication for HIV Therapy
Author(s) -
AO Isaac,
DD Wetkos,
AO Oche,
Isaac Okezie Godwin,
Phyllis J. Kanki,
AC John
Publication year - 2020
Publication title -
nigerian journal of clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.294
H-Index - 27
eISSN - 1119-3077
pISSN - 2229-7731
DOI - 10.4103/njcp.njcp_348_20
Subject(s) - cyp2b6 , efavirenz , medicine , genotype , single nucleotide polymorphism , pharmacogenetics , genotyping , human immunodeficiency virus (hiv) , virology , antiretroviral therapy , genetics , viral load , biology , cytochrome p450 , cyp3a4 , metabolism , gene
Africans exhibit great diversity in cytochrome P450 2B6 isoenzyme (CYP2B6), the major enzyme in efavirenz metabolism.