Open AccessPharmacokinetic behavior of phenytoin in head trauma and cerebrovascular accident patients in an iranian population
Author(s) -
Shahnaz Alimardani,
Sima Sadrai,
Hamidreza Taghvaye Masoumi,
Pooneh Salari,
Atabak Najafi,
Behzad Eftekhar,
Mojtaba Mojtahedzadeh
Publication year - 2017
Publication title -
journal of research in pharmacy practice
Language(s) - English
Resource type - Journals
eISSN - 2319-9644
pISSN - 2279-042X
DOI - 10.4103/jrpp.jrpp_17_58
Subject(s) - phenytoin , medicine , traumatic brain injury , pharmacokinetics , anesthesia , epilepsy , observational study , intensive care unit , head injury , anticonvulsant , prospective cohort study , surgery , psychiatry
Acute brain injury is one of the leading causes of morbidity and mortality worldwide. Phenytoin has been commonly used as an anticonvulsant agent for the treatment or prophylaxis of seizures following acute brain injury. After a severe head injury, several pharmacokinetic changes occur. The aim of this study is the comparative evaluation of phenytoin serum concentration in patients with traumatic and nontraumatic brain injury (TBI).