Open AccessEvaluation of the interaction of intravenous and oral voriconazole with oral cyclosporine in iranian HSCT patients
Author(s) -
Hamidreza Taghvaye Masoumi,
Molouk Hadjibabaie,
Mohammad Vaezi,
Ardeshir Ghavamzadeh
Publication year - 2017
Publication title -
journal of research in pharmacy practice
Language(s) - English
Resource type - Journals
eISSN - 2319-9644
pISSN - 2279-042X
DOI - 10.4103/jrpp.jrpp_16_163
Subject(s) - voriconazole , medicine , pharmacology , pharmacokinetics , oral administration , gastroenterology , drug interaction , hematopoietic stem cell transplantation , transplantation , antifungal , dermatology
Voriconazole as a triazole antifungal agent is widely used for prophylaxis or treatment of fungal infections in allogeneic hematopoietic stem cell transplantation (HSCT). It can increase blood concentrations of other medications including cyclosporine A (CsA) which are substrates for cytochrome P450 3A4. The aim of this study was to evaluate comparatively the interaction between oral/intravenous (IV) voriconazole and oral CsA.