Open AccessEarly post-operative hemodynamic perturbation associated with topiramate-induced metabolic acidosis: A case report
Author(s) -
Shalendra Singh,
Sujoy Banik,
Keshav Goyal,
Surya Kumar Dube
Publication year - 2018
Publication title -
journal of pediatric neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.247
H-Index - 18
eISSN - 1998-3948
pISSN - 1817-1745
DOI - 10.4103/jpn.jpn_86_17
Subject(s) - topiramate , metabolic acidosis , medicine , acidosis , hemodynamics , carbonic anhydrase , anesthesia , pharmacology , cardiology , endocrinology , enzyme , epilepsy , biochemistry , psychiatry , chemistry
Topiramate is a potent antiepileptic drug with multiple modes of action including inhibition of carbonic anhydrase activity. Inhibition of this enzyme predisposes to non-anion gap metabolic acidosis which has been amply described in the literature. However, the severity is yet to be well defined. We encountered a case of topiramate-induced non-anion gap metabolic acidosis associated with hemodynamic perturbations in an 8-year-old child in the postoperative period.