Early post-operative hemodynamic perturbation associated with topiramate-induced metabolic acidosis: A case report | Zendy

Keshav Goyal | Zendy; Shalendra Singh | Zendy; Sujoy Banik | Zendy; SuryaKumar Dube | Zendy

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Early post-operative hemodynamic perturbation associated with topiramate-induced metabolic acidosis: A case report

Author(s) -

Keshav Goyal,

Shalendra Singh,

Sujoy Banik,

SuryaKumar Dube

Publication year - 2018

Publication title -

journal of pediatric neurosciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.247

H-Index - 18

eISSN - 1998-3948

pISSN - 1817-1745

DOI - 10.4103/jpn.jpn_86_17

Subject(s) - topiramate , metabolic acidosis , medicine , acidosis , hemodynamics , carbonic anhydrase , anesthesia , pharmacology , cardiology , endocrinology , enzyme , epilepsy , biochemistry , psychiatry , chemistry

Topiramate is a potent antiepileptic drug with multiple modes of action including inhibition of carbonic anhydrase activity. Inhibition of this enzyme predisposes to non-anion gap metabolic acidosis which has been amply described in the literature. However, the severity is yet to be well defined. We encountered a case of topiramate-induced non-anion gap metabolic acidosis associated with hemodynamic perturbations in an 8-year-old child in the postoperative period.

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