Open AccessRecurrent aplastic anemia with donor-type aplasia: A rare occurrence in the Indian subcontinent
Author(s) -
Abdullah Al Shafi Majumder,
Satish Misra,
Vimal Kumar
Publication year - 2021
Publication title -
journal of postgraduate medicine/journal of postgraduate medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.405
H-Index - 52
eISSN - 0972-2823
pISSN - 0022-3859
DOI - 10.4103/jpgm.jpgm_988_20
Subject(s) - medicine , indian subcontinent , aplastic anemia , aplasia , incidence (geometry) , seriousness , pediatrics , population , bone marrow , etiology , surgery , immunology , environmental health , ancient history , physics , political science , law , optics , history
Donor-type aplasia (DTA) is a condition where an individual continues to be aplastic even after a successful engraftment of a hematopoeitic stem cell transplant with a majority of donor type cells in the bone marrow. This entity has been seen with varying frequency around the world, especially in Southeast Asia. However, its incidence in the Indian subcontinent remains fairly low. Here is a case of a 17-year-old child with DTA who had a 89% population of donor cells after a successful transplant and presented with recurrent severe aplastic anemia later. The patient eventually succumbed to his condition before a second transplant could be performed. The awareness about the seriousness of this relatively rare condition, therefore, needs to be emphasized.