Open AccessPolycystic ovary syndrome (PCOS) and kisspeptin – A Sri Lankan study
Author(s) -
B Umayal,
Surangi Jayakody,
N.V. Chandrasekharan,
W.S.S. Wijesundera,
Chandrika N. Wijeyaratne
Publication year - 2019
Publication title -
journal of postgraduate medicine/journal of postgraduate medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.405
H-Index - 52
eISSN - 0972-2823
pISSN - 0022-3859
DOI - 10.4103/jpgm.jpgm_683_17
Subject(s) - kisspeptin , polycystic ovary , endocrinology , medicine , testosterone (patch) , endocrine system , population , hyperandrogenism , context (archaeology) , hormone , biology , insulin resistance , obesity , environmental health , paleontology
Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder affecting young women. Kisspeptins are a family of closely related peptides encoded by Kiss1 gene that controls the hypothalamic-pituitary-gonadal axis by binding to its receptor (GPR54) expressed in gonadotropin-releasing hormone (GnRH) neurons and releases GnRH. Since GnRH secretion is deregulated in PCOS, we hypothesized that dysregulated gonadotropin secretion in PCOS is reflected by kisspeptin levels.