Open AccessAssociation of anti-CLIC2 and anti-HMGB1 autoantibodies with higher disease activity in systemic lupus erythematosus patients
Author(s) -
C S Syahidatulamali,
W G Wan Syamimee,
Y Nor Azwany,
Kah Keng Wong,
Che Hussin Che Maraina
Publication year - 2017
Publication title -
journal of postgraduate medicine/journal of postgraduate medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.405
H-Index - 52
eISSN - 0972-2823
pISSN - 0022-3859
DOI - 10.4103/jpgm.jpgm_499_16
Subject(s) - autoantibody , medicine , anti nuclear antibody , serology , immunology , rheumatology , systemic lupus erythematosus , hmgb1 , exact test , systemic disease , antibody , lupus erythematosus , autoimmune disease , disease , inflammation
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by numerous autoantibodies. In this study, we investigated the presence of anti-chloride intracellular channel 2 (anti-CLIC2) and anti-high mobility group box 1 (anti-HMGB1) autoantibodies in SLE patients (n = 43) versus healthy controls ([HCs] n = 43), and their association with serological parameters (antinuclear antibody [ANA], anti-double-stranded DNA [anti-dsDNA], and C-reactive protein [CRP]) and disease activity using Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score (active or inactive).