Open AccessEvaluation of the association between a single-nucleotide polymorphism of bone morphogenetic proteins 5 gene and risk of knee osteoarthritis
Author(s) -
Sharma Ac,
Srivastava Rn,
' Srivastava,
Ashok Kumar Agrahari,
Ajai Singh,
Devendra Parmar
Publication year - 2017
Publication title -
journal of postgraduate medicine/journal of postgraduate medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.405
H-Index - 52
eISSN - 0972-2823
pISSN - 0022-3859
DOI - 10.4103/jpgm.jpgm_450_16
Subject(s) - medicine , osteoarthritis , single nucleotide polymorphism , gene , bone morphogenetic protein , genetics , polymorphism (computer science) , bioinformatics , genotype , pathology , alternative medicine , biology
Osteoarthritis (OA) is a chronic degenerative disorder probably affected by both genetic and environmental causes. Bone morphogenetic proteins (BMPs) are bone-derived factors that can induce new bone formation. Single-nucleotide polymorphisms (SNPs) of BMP5 gene alters the transcriptional activity of the BMP5 promoter that has been involved in OA susceptibility. This case-control study investigated the association of rs1470527 and rs9382564 SNP of BMP5 gene with susceptibility to knee OA (KOA).