Open AccessProtective effect of Rheum turkestanicum against cisplatin by reducing oxidative stress in kidney tissue
Author(s) -
Azar Hosseini,
Sahar Fanoudi,
Hamid Mollazadeh,
Azita Aghaei,
Mohammad Taher Boroushaki
Publication year - 2018
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/jpbs.jpbs_9_18
Subject(s) - nephrotoxicity , creatinine , lipid peroxidation , cisplatin , oxidative stress , urinary system , kidney , pharmacology , chemistry , medicine , endocrinology , chemotherapy
Cisplatin is used as chemotherapeutic drug in the treatment of some solid tumors. It causes different side effects such as nephrotoxicity because of increasing oxidative stress and reactive oxygen species production. This study was designed to investigate the effect of Rheum turkestanicum on cisplatin-induced nephrotoxicity in rat.