Open AccessNano-hydroxyapatite: A driving force for bone tissue engineering
Author(s) -
Prem Blaisie Rajula,
Vivek Narayanan,
G. Devanand Venkatasubbu,
Rekha Mani,
Andra Sujana
Publication year - 2021
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/jpbs.jpbs_683_20
Subject(s) - biomedical engineering , bone grafting , bone tissue , regeneration (biology) , dentistry , bone healing , tissue engineering , orthopedic surgery , materials science , chemistry , nanotechnology , medicine , surgery , biology , microbiology and biotechnology
Bone is an amazing nanocomposite tissue made of both organic (primarily collagen) and inorganic (primarily nano-hydroxyapatite [n-HA]) elements. Bone grafting is a widely used surgical technique in dental and orthopedic surgeries to enhance bone regeneration. In view of the significant drawbacks of traditional treatments, nanomaterials offer new strategies for bone regeneration. The HA with the chemical formula of Ca 10 (OH) 2 (PO4) 6 is very identical to the inorganic portion of bone. Due to its high stability and minimal solubility, it is often used in orthopedic and dental procedures. Currently, n-HA, which facilitates the growth of new bone, has garnered considerable attention because of better bioactivity and bone integration ability when compared to porous HA. This review gives comprehensive insights related to n-HA structure, chemical composition, surface modification techniques, and their application in bone tissue engineering.