Open AccessScreening of potential phytocompounds from Euclea crispa (Thunb.) leaves targeting human epidermal growth factor receptor 2 (HER2) signaling pathway
Author(s) -
Chella Perumal Palanisamy,
Anofi Omotayo Tom Ashafa
Publication year - 2019
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/jpbs.jpbs_61_18
Subject(s) - adme , pharmacology , pharmacokinetics , epidermal growth factor receptor , chemistry , lipinski's rule of five , drug , in silico , traditional medicine , receptor , medicine , biochemistry , gene
Overexpression of human epidermal growth factor receptor 2 (HER2) plays an important role in the development and progression in a variety of cancers and it is a novel therapeutic target for breast cancer and ovarian cancer. Euclea crispa ( E. crispa ) is a South African medicinal plant in the family Ebenaceae used in the management of different human diseases and disorders.