Open AccessFibroblastic growth factor as a diagnostic and prognostic marker in odontogenic cysts and tumors: A systematic review
Author(s) -
Gururaj Narayana Rao,
Adlin Saroja Rosaian,
Gowthami Jawahar,
P Hari Nivas Raj,
J Beryl Rachel,
P Blessing Emmanuel
Publication year - 2021
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/jpbs.jpbs_563_20
Subject(s) - fibroblast growth factor , fibroblast growth factor receptor , pathological , biology , receptor tyrosine kinase , cancer research , odontogenic , growth factor , receptor , fibroblast growth factor receptor 1 , tyrosine kinase , pathology , bioinformatics , medicine , signal transduction , microbiology and biotechnology , genetics
Cellular signaling proteins maintain the basic activities of cell and communication, between the cells for normal growth and development and pathological situation as well. Fibroblast growth factor (FGF) and fibroblast growth factor receptors (FGFRs) have a comparatively huge part to play in the cellular communication processes. Human FGF has 22 members, 18 ligands, and 4 tyrosine kinase receptors for binding and is expressed in a wide range of cells. Any alteration in these factors would disrupt their normal function, leading to various abnormalities. The aim of this systematic analysis, is to understand the FGFs, the physiological and pathological role of FGF in oral diseases, and to predict the use of FGF in the predilection toward odontogenic cyst and tumors. This review helps confer the role of FGF in various physiological and pathological aspects in systemic diseases and analyzes its role in diagnosis and prognosis of odontogenic cysts and tumors.