Open AccessPotential deoxycytidine kinase inhibitory activity of amaryllidaceae alkaloids: An in silico approach
Author(s) -
Bashir A. Yousef,
Amina Ibrahim Dirar,
Mohamed Elbadawi,
Mohamed Awadalla,
Magdi A. Mohamed
Publication year - 2018
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/jpbs.jpbs_44_18
Subject(s) - amaryllidaceae alkaloids , in silico , deoxycytidine kinase , autodock , chemistry , docking (animal) , pharmacology , computational biology , biochemistry , stereochemistry , alkaloid , biology , deoxycytidine , medicine , genetics , nursing , chemotherapy , gemcitabine , gene
Plants of the Amaryllidaceae family have been under intense scrutiny for the presence of a couple of alkaloidal secondary metabolites with endued cytotoxic activity, such as pancratistatin ( 1 ), 7-deoxypancratistatin ( 2 ), narciclasine ( 3 ), 7-deoxynarciclasine ( 4 ), trans -dihydronarciclasine ( 5 ), and 7-deoxy- trans -dihydronarciclasine ( 6 ). Nevertheless, preclinical evaluation of these alkaloids has been put on hold because of the limited quantity of materials available from isolation.