Open AccessPharmacometrics approaches and its applications in diabetes: An overview
Author(s) -
SitiMaisharah Sheikh Ghadzi,
Sohail Aziz,
SabariahNoor Harun,
Syed Azhar Syed Sulaiman
Publication year - 2021
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/jpbs.jpbs_399_21
Subject(s) - viewpoints , diabetes mellitus , medicine , pharmacodynamics , intensive care medicine , computer science , insulin , risk analysis (engineering) , bioinformatics , pharmacokinetics , pharmacology , endocrinology , art , visual arts , biology
Type 2 diabetes mellitus is the most prevalent and progressive in nature. As the time progress, the multifaceted complications and comorbidities associated to diabetes worsen in the form of macrovascular or microvascular or both. Pharmacometrics modeling is a step forward in minimizing the risk or at least understanding the factors associated to its progression with the passage of time. These models investigate diabetes treatments effects and the progression factors with different viewpoints incorporating insulin-glucose dynamics, dose-response and pharmacokinetics, and pharmacodynamics relationships. Pharmacometrics modeling is an innovative approach in a sense that it is taking us away from the conventional analysis by providing all the opportunities in improving the decision-making in health sector. It has been suggested that we can achieve greater statistical power for determining drug effects through model-based evaluation than through traditional evaluations. The main aim of this review was to evaluate pharmacometrics approaches used in modeling diabetes progression through time and also the integrated models describing glucose-insulin dynamics.