Striatum hyperactivity triggers relapse to morphine and methamphetamine (polydrug) dependence in mice | Zendy

Nur Syafinaz Wasli | Zendy; Irna Elina Ridzwan | Zendy; Marwan Saad Azzubaidi | Zendy; Abdul Razak Kasmuri | Zendy; Qamar Uddin Ahmed | Zendy; Long Chiau Ming | Zendy; Nornisah Mohamed | Zendy; Syed Mohd Syahmi Syd Mohmad Faudzi | Zendy

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Striatum hyperactivity triggers relapse to morphine and methamphetamine (polydrug) dependence in mice

Author(s) -

Nur Syafinaz Wasli,

Irna Elina Ridzwan,

Marwan Saad Azzubaidi,

Abdul Razak Kasmuri,

Qamar Uddin Ahmed,

Long Chiau Ming,

Nornisah Mohamed,

Syed Mohd Syahmi Syd Mohmad Faudzi

Publication year - 2020

Publication title -

journal of pharmacy and bioallied sciences

Language(s) - English

Resource type - Journals

eISSN - 0976-4879

pISSN - 0975-7406

DOI - 10.4103/jpbs.jpbs_379_19

Subject(s) - striatum , buprenorphine , nucleus accumbens , naltrexone , addiction , conditioned place preference , methamphetamine , pharmacology , opioid , antagonist , medicine , morphine , psychology , psychiatry , receptor , dopamine

κ-opioid receptor (KOPr) system has been linked to relapse to many substances, especially opioids. Positive responses were recently reported in morphine and methamphetamine (polydrug)-dependent mice treated with buprenorphine and naltrexone, a functional κ antagonist.

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