Open AccessStriatum hyperactivity triggers relapse to morphine and methamphetamine (polydrug) dependence in mice
Author(s) -
Nur Syafinaz Wasli,
Irna Elina Ridzwan,
Marwan Saad Azzubaidi,
Abdul Razak Kasmuri,
Qamar Uddin Ahmed,
Long Chiau Ming,
Norita Mohamed,
Syed Mohd Syahmi Syd Mohmad Faudzi
Publication year - 2020
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/jpbs.jpbs_379_19
Subject(s) - striatum , buprenorphine , nucleus accumbens , naltrexone , addiction , conditioned place preference , methamphetamine , pharmacology , opioid , antagonist , medicine , morphine , psychology , psychiatry , receptor , dopamine
κ-opioid receptor (KOPr) system has been linked to relapse to many substances, especially opioids. Positive responses were recently reported in morphine and methamphetamine (polydrug)-dependent mice treated with buprenorphine and naltrexone, a functional κ antagonist.