Open AccessInhibition of pancreatic elastase in silico and in vitro by Rubus rosifolius leaves extract and its constituents
Author(s) -
Yesi Desmiaty,
Esti Mulatsari,
Fadlina Chany Saputri,
Muhammad Hanafi,
Rini Prastiwi,
Berna Elya
Publication year - 2020
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/jpbs.jpbs_271_19
Subject(s) - ellagic acid , elastase , chemistry , docking (animal) , biochemistry , pancreatic elastase , enzyme , protein data bank (rcsb pdb) , ethyl acetate , antioxidant , polyphenol , medicine , nursing
Elastases are protease enzymes, which mainly hydrolyze proteins of the connective tissue, so they have a significant impact on human disease. Rubus rosifolius is one of the Rubus species found in Indonesian mountains, and it has potential as an elastase inhibitor. The objective of this research was to examine the in vitro elastase inhibitor activity of R. rosifolius leaves and to dock different ligands of its constituents against target protein of Porcine Pancreatic Elastase (PPE) receptor.