Open AccessInfluence of DRD2 polymorphisms on the clinical outcomes of opioiddependent patients on methadone maintenance therapy
Author(s) -
Zalina Zahari,
Chee Siong Lee,
Muslih Abdulkarim Ibrahim,
Nurfadhlina Musa,
Mohd Azhar Mohd Yasin,
Yeong Yeh Lee,
Soo Choon Tan,
Nasir Mohamad,
Rusli Ismail
Publication year - 2020
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/jpbs.jpbs_248_19
Subject(s) - taqi , medicine , opioid , rs4680 , pittsburgh sleep quality index , methadone , pain tolerance , opiate , oncology , polymorphism (computer science) , threshold of pain , psychiatry , insomnia , genotype , sleep quality , receptor , biology , genetics , gene
Dopamine receptor D2 (DRD2) is one of the dopamine receptors that have been studied in relation to opioid dependence. It is possible, therefore, that DRD2 gene ( DRD2 ) polymorphisms influence treatment outcomes of patients with opioid dependence. The objective of this study was to investigate the influence of DRD2 polymorphisms on the clinical outcomes of opioid-dependent patients on methadone maintenance therapy (MMT).