Open AccessStandardization of type 1 and type 2 diabetic nephropathy models in rats: Assessment and characterization of metabolic features and renal injury
Author(s) -
Aakruti Kaikini,
Divya Dhodi,
Suraj Muke,
Vaibhavi Peshattiwar,
Sneha Bagle,
Aruna Korde,
Jayula Sarnaik,
Vijay Kadwad,
S.S. Sachdev,
Sadhana Sathaye
Publication year - 2020
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/jpbs.jpbs_239_19
Subject(s) - medicine , insulin resistance , diabetes mellitus , type 2 diabetes , hyperinsulinemia , type 1 diabetes , nephropathy , type 2 diabetes mellitus , insulin , population , diabetic nephropathy , endocrinology , bioinformatics , biology , environmental health
Diabetes mellitus and its complications, such as nephropathy, represent a global burden. Recent research focuses on developing drugs that specifically target the pathogenesis of diabetic nephropathy rather than merely treating hyperglycemia. Rodent models of animal disease are integral in drug discovery and represent an obligatory regulatory requirement.