Open AccessPolymorphism of TPH2 gene rs120074175 is not associated with risk factors of schizophrenia
Author(s) -
James P Laksono,
Riyadi Sumirtanurdin,
Haafizah Dania,
Fitri N Ramadhani,
Dyah Aryani Perwitasari,
Rizky Abdulah,
Melisa Intan Barliana
Publication year - 2019
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/jpbs.jpbs_216_19
Subject(s) - tph2 , ethidium bromide , tryptophan hydroxylase , genotype , schizophrenia (object oriented programming) , allele , genetics , medicine , gene , serotonin , psychiatry , biology , dna , receptor , serotonergic
Polymorphism on tryptophan hydroxylase 2 ( TPH2 ) gene rs120074175 can cause the synthesis of neurotransmitter serotonin in the brain to reduce up to 80%. Reduced serotonin in the brain can cause dopamine release to occur continuously. Excess dopamine in the brain may cause positive symptom of schizophrenia.