Open AccessImmunohistochemical expression of ezrin in oral potentially malignant disorders-A descriptive study
Author(s) -
Raghini Mohanraj,
Pratibha Ramani,
Priya Premkumar,
Anuja Natesan,
Herald J Sherlin,
S Gheena
Publication year - 2017
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/jpbs.jpbs_139_17
Subject(s) - ezrin , oral submucous fibrosis , immunohistochemistry , pathology , malignant transformation , medicine , dysplasia , leukoplakia , hyperkeratosis , cell , biology , cancer , genetics , cytoskeleton
Ezrin, also known as cytovillin, is a member of the ERM family of protein. Ezrin cross-links actin filament with the plasma membrane. They are involved in the formation of microvilli, cell-cell adhesion, maintenance of cell shape, cell motility, and membrane trafficking. Recent analysis reveals their involvement in signaling pathways. Ezrin is highly expressed in several types of human cancers, and correlation between its immunoreactivity and histopathological data as well as the patient outcome has previously been studied.