Cysteine supplementation mitigates the toxicity associated with antitumor therapy of Ehrlich’s ascites fluid adsorbed over protein a containing Staphylococcus aureus cowan I† | Zendy

AshishS Verma | Zendy; A.K. Singh | Zendy; Priyadarshini Mallick | Zendy; PremendraD Dwivedi | Zendy

Open Access

Cysteine supplementation mitigates the toxicity associated with antitumor therapy of Ehrlich’s ascites fluid adsorbed over protein a containing Staphylococcus aureus cowan I^†

Author(s) -

AshishS Verma,

A.K. Singh,

Priyadarshini Mallick,

PremendraD Dwivedi

Publication year - 2019

Publication title -

journal of pharmacy and bioallied sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.268

H-Index - 36

eISSN - 0976-4879

pISSN - 0975-7406

DOI - 10.4103/jpbs.jpbs_108_18

Subject(s) - glutathione , ascites , toxicity , cysteine , medicine , enzyme , chemistry , pharmacology , cancer research , biochemistry

Previously, we have reported the amelioration of ad-AF induced hepatotoxicity with the exogenous supplementation of glutathione (GSH) without compromising the anti-tumor effect of ad-AF in ascites tumor model of mice with transplantable Ehrlich's Ascites Tumor cells. Cellular uptake of glutathione (GSH) has its own limitations, therefore exogenous supplementation of L-cysteine (Cys) was tried to reduce the toxicity of ad-AF by providing -SH contents without compromising the anti-tumor property of adsorbed ascites fluid (ad-AF).

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