Open AccessTrichostatin a restores expression of adherens and tight junction proteins during transforming growth factor β-Mediated epithelial-to-mesenchymal transition
Author(s) -
Darshini Ganatra,
Abhay R. Vasavada,
Nair G Vidya,
Devarshi Gajjar,
S Rajkumar
Publication year - 2018
Publication title -
journal of ophthalmic and vision research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.557
H-Index - 27
eISSN - 2008-2010
pISSN - 2008-322X
DOI - 10.4103/jovr.jovr_110_17
Subject(s) - adherens junction , trichostatin a , epithelial–mesenchymal transition , histone deacetylase , microbiology and biotechnology , chromatin immunoprecipitation , biology , cancer research , histone , cadherin , cell , gene expression , downregulation and upregulation , genetics , promoter , gene
Adherens junctions and polarity markers play an important role in maintaining epithelial phenotype but get altered during the epithelial-mesenchymal transition (EMT). Alterations of these markers during EMT of lens epithelial cell (LEC) can lead to vision compromising conditions. The aim of this study was to examine if Trichostatin-A (TSA), a histone deacetylase inhibitor, can prevent EMT by restoring the adherens junction complex in LEC.