Open AccessEvaluation of immunohistochemical expression of epithelial–mesenchymal transition markers E-cadherin, Twist and Snail in oral submucous fibrosis and their possible association with malignant transformation
Author(s) -
Mahadevi B. Hosur,
Rudrayya S Puranik,
Shrinivas S. Vanaki,
Surekha R Puranik,
M Sudhakara,
Sushma Das
Publication year - 2021
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/jomfp.jomfp_454_20
Subject(s) - oral submucous fibrosis , epithelial–mesenchymal transition , immunohistochemistry , cadherin , epithelial dysplasia , dysplasia , pathology , malignant transformation , twist transcription factor , transition (genetics) , biology , medicine , cancer , metastasis , cell , gene , biochemistry , genetics
Oral submucous fibrosis (OSMF) is a chronic, potentially malignant condition of the oral mucosa, predominantly seen in people of Asian descent. The reported malignant transformation rate of OSMF is 7%-13%. In the context of the understanding progression of OSMF, the study of prime molecular expressions is essential. Various markers have received more attention, one of them is E-cadherin. Various factors which promote epithelial-mesenchymal transition (EMT) and inhibit E-Cadherin include Snail1, Snail2, Twist and EF1/ZEB1. The intended study was undertaken to evaluate the possible role of E-cadherin and its regulatory markers Twist1 and Snail1 in OSMF.