Open AccessOral medullary plasmacytoma: Rare case reports
Author(s) -
Malathi Narasimhan,
Ravindran Chinnaswamy,
G V V Giri,
Vijayanirmala Subramani
Publication year - 2020
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/jomfp.jomfp_37_19
Subject(s) - hematopathology , medicine , dyscrasia , plasmacytoma , plasma cell , medullary cavity , pathology , multiple myeloma , lesion , bone marrow , plasma cell dyscrasia , differential diagnosis , bone pain , immunology , antibody , biology , immunoglobulin light chain , biochemistry , cytogenetics , chromosome , gene
Medullary plasmacytoma (MP) or osseous or solitary bone plasmacytoma is a specializing hematopathology lesion typically present with local symptoms, such as pain, paresthesia and pathologic bone fractures as a result of proliferation of plasma cells. The most often involved sites are active hematopoietic long bones and the vertebrae. The clinical course of disease is identical to spectrum of other plasma cell dyscrasias. The diagnostic criteria include punched-out radiolucencies, monoclonal plasma cells and M protein. This lesion should be considered for the differential diagnosis of bone tumors. It is highly radiosensitive although combination modalities of radiation, surgery and chemotherapy have been used in the treatment. The long-term follow-up is essential. We report two rare cases of oral MP with unusual clinical presentation.