Open AccessAntifungal activity of solvent extracts of Piper betle and Ocimum sanctum Linn on Candida albicans: An in vitro comparative study
Author(s) -
Basireddy Sivareddy,
Bernard Ajay Reginald,
D Sireesha,
Meda Samatha,
Kumar Reddy,
G Subrahamanyam
Publication year - 2019
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/jomfp.jomfp_167_19
Subject(s) - piper , candida albicans , fluconazole , ocimum , traditional medicine , antimicrobial , ethyl acetate , minimum inhibitory concentration , corpus albicans , chemistry , biology , antifungal , microbiology and biotechnology , medicine , chromatography
Oral candidiasis is a common fungal infection caused by Candida albicans . In recent years, Candida species have shown resistance against many synthetic drugs, which has highlighted the need for novel antifungal drugs with fewer side effects for effective management of candidiasis. Several studies have suggested that some plant species possess promising antimicrobial compounds. Piper betle and Ocimum sanctum Linn are such common medicinal plants that show strong antimicrobial activity by the release of secondary metabolites. However, the effect of these plants on oral candidiasis has not been studied and hence, the present study aimed to evaluate the antifungal activity of these plant extracts on the subcultures of C. albicans and compared with a standard drug, fluconazole.