Open AccessDetection of human papilloma virus-E6/E7 proteins of high-risk human papilloma virus in saliva and lesional tissue of oral squamous cell carcinoma patients using nested multiplex polymerase chain reaction: A comparative study
Author(s) -
Rajbir Kaur Grewal,
Keya Sircar,
Kishore Bhat,
Dilpreet Singh Grewal,
Krishan Kumar Tyagi,
David Schwesig
Publication year - 2018
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/jomfp.jomfp_15_18
Subject(s) - saliva , polymerase chain reaction , multiplex polymerase chain reaction , human papilloma virus , basal cell , tongue , papilloma , nested polymerase chain reaction , biology , cancer , multiplex , clinical significance , carcinoma , medicine , pathology , cancer research , gene , cervical cancer , bioinformatics , genetics
Human papilloma virus (HPV)-associated oral squamous cell carcinoma (OSCC) shows different biological behavior as compared to tobacco-induced OSCC. Mere presence of HPV in OSCC is of no clinical significance; however, the integration of HPV-DNA through E6/E7 gene into the host genome is important as it affects the development and progression of OSCC.