Open AccessThe expression of Bcl-2 in oral squamous cell carcinoma—A review
Author(s) -
Arumugam Jayakumar,
Nadeem Jeddy,
Ananthalakshmi Ramamurthy,
Radhika Thangavelu
Publication year - 2017
Publication title -
journal of orofacial sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.171
H-Index - 6
eISSN - 2320-4737
pISSN - 0975-8844
DOI - 10.4103/jofs.jofs_88_16
Subject(s) - basal cell , cancer research , cancer , medicine , apoptosis , protein expression , cell , oncology , biology , gene , genetics
Currently, oral cancer is one of the most alarming health problems facing mankind. More than 90% of all oral cancers are oral squamous cell carcinoma (OSCC). BCL-2 proteins are one of the most prominent anti-apoptotic proteins expressed in OSCC. They contribute to cancer development and mediate resistance to current anticancer treatments. Various studies have been conducted to evaluate the expression of Bcl-2 in OSCC. This article emphasizes the importance of Bcl-2 expression as a prognostic indicator in OSCC