The expression of Bcl-2 in oral squamous cell carcinoma—A review | Zendy

Arumugam Jayakumar | Zendy; Nadeem Jeddy | Zendy; Ananthalakshmi Ramamurthy | Zendy; Radhika Thangavelu | Zendy

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The expression of Bcl-2 in oral squamous cell carcinoma—A review

Author(s) -

Arumugam Jayakumar,

Nadeem Jeddy,

Ananthalakshmi Ramamurthy,

Radhika Thangavelu

Publication year - 2017

Publication title -

journal of orofacial sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.171

H-Index - 6

eISSN - 2320-4737

pISSN - 0975-8844

DOI - 10.4103/jofs.jofs_88_16

Subject(s) - basal cell , cancer research , cancer , medicine , apoptosis , protein expression , cell , oncology , biology , gene , genetics

Currently, oral cancer is one of the most alarming health problems facing mankind. More than 90% of all oral cancers are oral squamous cell carcinoma (OSCC). BCL-2 proteins are one of the most prominent anti-apoptotic proteins expressed in OSCC. They contribute to cancer development and mediate resistance to current anticancer treatments. Various studies have been conducted to evaluate the expression of Bcl-2 in OSCC. This article emphasizes the importance of Bcl-2 expression as a prognostic indicator in OSCC

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