Open AccessEvaluation of hTERT gene expression and chromosome 7 copy number variation in anal squamous intra-epithelial lesions: A pilot study
Author(s) -
Neelam Wadhwa,
Tanvi Arora,
Divya Aggarwal,
Deepika Pandhi,
Preeti Diwaker,
VinodK Arora
Publication year - 2022
Publication title -
journal of cytology/journal of cytology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.267
H-Index - 19
eISSN - 0974-5165
pISSN - 0970-9371
DOI - 10.4103/joc.joc_26_21
Subject(s) - telomerase reverse transcriptase , carcinogenesis , chromosome , ascus (bryozoa) , medicine , pathology , biology , gene , cancer research , telomerase , genetics , botany , ascospore , spore
Akin to cervical squamous intra-epithelial neoplasia (CIN), anal squamous intra-epithelial lesion (a-SIL) is attributed to persistent infection with high-risk human papilloma virus infection. Amplification of human telomerase reverse transcriptase (hTERT) gene and aneuploidy are known to correlate with CIN evolution. It is plausible that the underlying genetic events in a-SIL are similar. We conducted this cross-sectional analytical study with the objective of determining expression of hTERT gene expression and chromosome 7, as marker of cell ploidy in a-SIL.