Evaluation of hTERT Gene Expression and Chromosome 7 Copy Number Variation in Anal Squamous Intra-Epithelial Lesions | Zendy

Tanvi Arora | Zendy; Neelam Wadhwa | Zendy; Divya Aggarwal | Zendy; Deepika Pandhi | Zendy; Preeti Diwaker | Zendy; Vinod K. Arora | Zendy

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Evaluation of hTERT Gene Expression and Chromosome 7 Copy Number Variation in Anal Squamous Intra-Epithelial Lesions

Author(s) -

Tanvi Arora,

Neelam Wadhwa,

Divya Aggarwal,

Deepika Pandhi,

Preeti Diwaker,

Vinod K. Arora

Publication year - 2022

Publication title -

journal of cytology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.267

H-Index - 19

eISSN - 0974-5165

pISSN - 0970-9371

DOI - 10.4103/joc.joc_26_21

Subject(s) - telomerase reverse transcriptase , chromosome , ascus (bryozoa) , carcinogenesis , pathology , medicine , biology , gene , cancer research , telomerase , genetics , botany , ascospore , spore

Akin to cervical squamous intra-epithelial neoplasia (CIN), anal squamous intra-epithelial lesion (a-SIL) is attributed to persistent infection with high-risk human papilloma virus infection. Amplification of human telomerase reverse transcriptase (hTERT) gene and aneuploidy are known to correlate with CIN evolution. It is plausible that the underlying genetic events in a-SIL are similar. We conducted this cross-sectional analytical study with the objective of determining expression of hTERT gene expression and chromosome 7, as marker of cell ploidy in a-SIL.

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