Open AccessDiagnostic value of S100P, IMP3, Maspin, and pVHL in the differantial diagnosis of pancreatic ductal adenocarcinoma and normal/chronic pancreatitis in fine needle aspiration biopsy
Author(s) -
Ayşegül Aksoy-Altinboga,
Tolga Bağlan,
Haldun Umudum,
Koray Ceyhan
Publication year - 2018
Publication title -
journal of cytology/journal of cytology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.267
H-Index - 19
eISSN - 0974-5165
pISSN - 0970-9371
DOI - 10.4103/joc.joc_18_17
Subject(s) - medicine , maspin , malignancy , triple test , pancreatitis , pathology , fine needle aspiration , biopsy , pancreas , adenocarcinoma , pancreatic ductal adenocarcinoma , pancreatic cancer , cancer , metastasis , pregnancy , fetus , biology , genetics
Differentiation between pancreatic ductal adenocarcinoma (PDAC) from benign mimickers is a well-known problem in cytological materials. Recent studies incorporated biological markers into this question and some studies showed that expression of S100P, IMP3, and maspin as well as nonexpression of von Hippel-Lindau gene product (pVHL) were significantly correlated with PDAC. In this study, we aimed to investigate diagnostic value of maspin, IMP3, S100P, and pVHL immunostaining in fine needle aspiration biopsies (FNABs) of pancreatic lesions.