Open AccessEvaluation of p16/Ki-67 dual staining compared with HPV genotyping in anal cytology with diagnosis of ASC-US for detection of high-grade anal intraepithelial lesions
Author(s) -
Maxime Pichon,
M Joly,
F. Lebreton,
M Benchaib,
Yahia Mekki,
Mojgan DevouassouxShisheboran
Publication year - 2019
Publication title -
journal of cytology/journal of cytology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.267
H-Index - 19
eISSN - 0974-5165
pISSN - 0970-9371
DOI - 10.4103/joc.joc_131_18
Subject(s) - squamous intraepithelial lesion , cytology , genotyping , anal cancer , medicine , hpv infection , biopsy , staining , pathology , cervical cancer , cancer , genotype , cervical intraepithelial neoplasia , biology , biochemistry , gene
Human Papillomavirus (HPV) infection is the main risk factor for anogenital cancer. The objective of this study was to compare p16/Ki-67 dual staining to HPV genotyping in anal cytology samples with an atypical squamous cell of undetermined significance (ASC-US) for the identification of high-grade squamous intraepithelial lesion (HSIL).