Open AccessLack of influence of dexmedetomidine on rat glomus cell response to hypoxia, and on mouse acute hypoxic ventilatory response
Author(s) -
Peadar B. O’Donohoe,
Philip J. Turner,
Nicky Huskens,
Keith J. Buckler,
J. J. Pandit
Publication year - 2021
Publication title -
journal of anaesthesiology-clinical pharmacology/journal of anaesthesiology clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.466
H-Index - 32
eISSN - 2231-2730
pISSN - 0970-9185
DOI - 10.4103/joacp.joacp_309_16
Subject(s) - dexmedetomidine , medicine , glomus cell , anesthesia , hypoxia (environmental) , hypoxic ventilatory response , carotid body , stimulation , pharmacology , endocrinology , respiratory system , sedation , chemistry , oxygen , organic chemistry
There is a lack of basic science data on the effect of dexmedetomidine on the hypoxic chemosensory reflex with both depression and stimulation suggested. The primary aim of this study was to assess if dexmedetomidine inhibited the cellular response to hypoxia in rat carotid body glomus cells, the cells of the organs mediating acute hypoxic ventilatory response (AHVR). Additionally, we used a small sample of mice to assess if there was any large influence of subsedative doses of dexmedetomidine on AHVR.