Open AccessEffects of two different doses of 3% hypertonic saline with mannitol during decompressive craniectomy following traumatic brain injury: A prospective, controlled study
Author(s) -
Neelesh Bhatnagar,
Saurabh Bhateja,
Lalita Jeenger,
Govind Mangal,
Somesh Gupta
Publication year - 2021
Publication title -
journal of anaesthesiology-clinical pharmacology/journal of anaesthesiology clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.466
H-Index - 32
eISSN - 2231-2730
pISSN - 0970-9185
DOI - 10.4103/joacp.joacp_169_18
Subject(s) - medicine , hypertonic saline , mannitol , anesthesia , traumatic brain injury , glasgow coma scale , decompressive craniectomy , glasgow outcome scale , craniotomy , saline , osmole , surgery , chemistry , organic chemistry , psychiatry
The current study was designed to compare the effects of two different doses of 3% hypertonic saline with mannitol on intraoperative events during decompressive craniectomy in traumatic brain injury (TBI). Primary outcome measures included assessment of intraoperative brain relaxation, hemodynamic variables, and serum electrolytes. Effect on the postoperative outcome, in terms of the Glasgow coma scale (GCS), length of stay in the ICU, and mortality were the secondary outcome measures.